MetFix Medical Nutrition

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Intermediate4 decision points

The Statin Paradox

Interpreting lipid panels in the context of insulin resistance

Learning Objectives

  • Interpret lipid panels in the context of insulin resistance
  • Understand the limitations of LDL-C as a cardiovascular risk marker
  • Apply ApoB and particle size data to clinical decision-making
Step 1 of 4Presentation

Patricia L., 56F, is referred by her cardiologist for dietary counseling. She has been on atorvastatin 40mg for 3 years after her LDL-C reached 148 mg/dL. Her current labs on statin: LDL-C 72 mg/dL, total cholesterol 142, HDL 38, TG 224, fasting glucose 112 mg/dL, HbA1c 5.8%. Her cardiologist is pleased with her LDL response. She has gained 18 lbs since starting the statin and reports new fatigue and muscle aches.

Patricia's metabolic profile on statin therapy is most concerning because: