MetFix Medical Nutrition

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Intermediate4 decision points

The Lean Diabetic

Insulin resistance in the absence of obesity

Learning Objectives

  • Recognize that insulin resistance can occur in lean individuals
  • Identify ectopic fat deposition as a mechanism of lean metabolic disease
  • Apply the Insulin/ROS Hypothesis to a non-obese patient
Step 1 of 4Presentation

Jennifer K., 38F, BMI 22.4, presents for a routine physical. She is a marathon runner who eats a 'clean' high-carbohydrate diet (pasta, rice, fruit, whole grains) to fuel her training. She has no symptoms and feels well. Her physician is surprised to find: fasting glucose 108 mg/dL, HbA1c 5.9%, TG 142, HDL 38, fasting insulin 18.4 μIU/mL, HOMA-IR 4.9, ALT 52 U/L.

Jennifer's elevated ALT in the context of her metabolic profile most likely indicates: